Tea at Trianon: Dirt and Antibiotics

John Wilson Croker on Marie-Antoinette

"We have followed the history of Marie Antoinette with the greatest diligence and scrupulosity. We have lived in those times. We have talked with some of her friends and some of her enemies; we have read, certainly not all, but hundreds of the libels written against her; and we have, in short, examined her life with– if we may be allowed to say so of ourselves– something of the accuracy of contemporaries, the diligence of inquirers, and the impartiality of historians, all combined; and we feel it our duty to declare, in as a solemn a manner as literature admits of, our well-matured opinion that every reproach against the morals of the queen was a gross calumny– that she was, as we have said, one of the purest of human beings."

~from History of the Guillotine by John Wilson Croker, 1844

Edmund Burke on Marie-Antoinette

"It is now sixteen or seventeen years since I saw the queen of France, then dauphiness, at Versailles; and surely there never lighted on this orb, which she hardly seemed to touch, a more delightful vision. I saw her just above the horizon, decorating and cheering the elevated sphere she had just begun to move in, glittering like a morning star full of life and splendor and joy. Oh, what a revolution....Little did I dream that I should have lived to see such disasters fall upon her, in a nation of gallant men, in a nation of men of honor and of cavaliers! I thought ten thousand swords must have leaped from their scabbards, to avenge even a look which threatened her with insult. But the age of chivalry is gone; that of sophisters, economists, and calculators has succeeded...."

~Edmund Burke, October 1790

Tuesday, February 27, 2018

Dirt and Antibiotics

From the BBC:

Soil is teeming with millions of different micro-organisms that produce lots of potentially therapeutic compounds, including new antibiotics. Dr Sean Brady's team at New York's Rockefeller University has been busy unearthing them. They used a gene sequencing technique to analyse more than 1,000 soil samples taken from across the US. When they discovered malacidins in many of the samples, they had a hunch it was an important find. They tested the compound on rats that they had given MRSA and it eliminated the infection in skin wounds. The researchers are now working to improve the drug's effectiveness in the hope that it can be developed into a real treatment for people.

Dr Brady said: "It is impossible to say when, or even if, an early stage antibiotic discovery like the malacidins will proceed to the clinic. "It is a long, arduous road from the initial discovery of an antibiotic to a clinically used entity." (Read more.)