Tea at Trianon: Fentanyl Exposure

John Wilson Croker on Marie-Antoinette

"We have followed the history of Marie Antoinette with the greatest diligence and scrupulosity. We have lived in those times. We have talked with some of her friends and some of her enemies; we have read, certainly not all, but hundreds of the libels written against her; and we have, in short, examined her life with– if we may be allowed to say so of ourselves– something of the accuracy of contemporaries, the diligence of inquirers, and the impartiality of historians, all combined; and we feel it our duty to declare, in as a solemn a manner as literature admits of, our well-matured opinion that every reproach against the morals of the queen was a gross calumny– that she was, as we have said, one of the purest of human beings."

~from History of the Guillotine by John Wilson Croker, 1844

Edmund Burke on Marie-Antoinette

"It is now sixteen or seventeen years since I saw the queen of France, then dauphiness, at Versailles; and surely there never lighted on this orb, which she hardly seemed to touch, a more delightful vision. I saw her just above the horizon, decorating and cheering the elevated sphere she had just begun to move in, glittering like a morning star full of life and splendor and joy. Oh, what a revolution....Little did I dream that I should have lived to see such disasters fall upon her, in a nation of gallant men, in a nation of men of honor and of cavaliers! I thought ten thousand swords must have leaped from their scabbards, to avenge even a look which threatened her with insult. But the age of chivalry is gone; that of sophisters, economists, and calculators has succeeded...."

~Edmund Burke, October 1790

Tuesday, May 16, 2023

Fentanyl Exposure

From PsyPost:

New research sheds light on the brain circuits involved in addiction to opioids like fentanyl. The findings, published in Cell Reports, indicate that that chronic opioid exposure triggers a series of changes in the brain that results in a hypodopaminergic state. This state may underlie the mechanism of anxiety-like behaviors during acute opioid withdrawal.
Opioid addiction has become a global epidemic, with millions of people suffering from its devastating effects. Opioids are highly addictive drugs that act on the brain’s reward system, producing feelings of pleasure and euphoria. However, with prolonged use, opioids can lead to a range of negative emotional states, including anxiety, depression, and irritability, which can trigger relapse. (Read more.)